‘Of course, that's about appropriate. I search for a Bodily comprehension of biological techniques in a very bottom-up way. I believe you could possibly distinguish three lines of investigation in my group at the moment. The main problems chromosome structure: How would you have a metre-very long DNA polymer folded and organised in such a microscopic cell? We have now formulated visualisation methods that enable us to review how, for example, SMC proteins loop DNA (video clip on Youtube) so as to build up chromosomes.
Our group reports bacterial cell division and is aiming to represent a ‘base up biology’ in synthetic cells that may autonomously divide. Our most important desire lies in mobile division, chromatin structure, and spatial control.
Multicolor imaging on the bacterial nucleoid and cell division proteins with blue, orange, and around-infrared fluorescent proteins
Sculpting nano-electrodes which has a transmission electron beam for electrical and geometrical characterization of nanoparticles.
To look through Academia.edu and the broader internet more quickly plus more securely, please take a handful of seconds to up grade your browser.
Our analysis ranges through the biophysics of DNA to synthetic cells and over and above. Remember to have a look beneath on the spectrum of our existing initiatives.
Quite a few similar developments adopted, where our group set up various transistor variants including solitary-electron transistors at area temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled a number of transistors into modest evidence-of-theory electronic circuits.
Instance (one) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is revealed in grey, the rim of your pore is highlighted in purple, and a 3D rendering with the motion on the DNA rod is displayed.
‘Indeed, I realize folks have been astonished at enough time. At the conclusion of the nineties, when I was in my forties, I had been Professor of Molecular Electronics and I've to admit that it had turn into a bit bored, I didn’t learn much any more. The sphere went far more into the applying side, how you may combine nanotubes into Digital circuits.
Resolving the action dimensions in condensin-pushed DNA loop extrusion identifies ATP binding since the phase-creating approach
‘The concept there is such a issue for a commencing, a big bang, is presently an interesting signpost to look at that there was a creator. But more usually, and on cees dekker The idea of pure rationality, I also arrive at a Christian interpretation of fact. An atheistic worldview is often a naturalistic worldview: essentially, there are actually only atoms and natural forces that we are able to measure.
‘That issues the artificial mobile, as Portion of the Dutch BaSyC initiative. Craig Venter appeared leading-down in All those days and recognized about 5 hundred genes which are minimally expected for a working mobile. We wish to search base-up: how can we move from a few molecules to a whole Organic procedure?
Visualization of unstained DNA nanostructures with Highly developed in-focus transmission electron microscopy strategies
The biophysicist from Delft – who continues to be Probably the most cited scientists in the Netherlands For some time – usually takes his accountability to lead for the clarification and popularisation of his function at the border of physics and biology exceptionally very seriously and often appears within the media; Otherwise to mention his perform, then about the relationship concerning science and his Christian religion.